Asymmetric Synthesis Enabled by Organometallic Complexes
نویسندگان
چکیده
منابع مشابه
Ate complexes of secondary boronic esters as chiral organometallic-type nucleophiles for asymmetric synthesis.
The addition of an aryllithium reagent to a secondary boronic ester leads to an intermediate boron-ate complex that behaves as a chiral nucleophile, reacting with a broad range of electrophiles with inversion of stereochemistry. Depending on the electrophile, the C-B bond can be converted into C-I, C-Br, C-Cl, C-N, C-O, and C-C, all with very high levels of stereocontrol. This discovery now add...
متن کاملAsymmetric Synthesis Using Organometallic Reagents and Optically Pure Vinylic Sulfoxides
A new, general method is developed for preparation of various 3-substituted carbonyl compounds of very high optical purity. Application of this method is made to asymmetric synthesis of either enantiomer of 3—methylalkanoic acids, of optically pure 3-methylcyclopentanone, 3—methylcyclohexanone, 3-naphthylcyclopentanone and 3-vinylcyclopentanone j. 9,11-Seco steroid and steroid intermediate are ...
متن کاملSynthesis, Molecular Docking and Cytotoxic Activity Evaluation of Organometallic Thiolated Gold(I) Complexes
The complex [(PhCH2NC)AuCl], 1, was prepared by the reaction of [(Me2S)AuCl], A, with an equimolar amount of benzyl isocyanide (PhCH2NC) ligand. Through a salt metathesis reaction, the chloride ligand in 1 was replaced by potassium benzothiazole-2-thiolate (Kbt) and potassium benzoimidazole-2-thiolate (Kbi) to a...
متن کاملSynthesis, Molecular Docking and Cytotoxic Activity Evaluation of Organometallic Thiolated Gold(I) Complexes
The complex [(PhCH2NC)AuCl], 1, was prepared by the reaction of [(Me2S)AuCl], A, with an equimolar amount of benzyl isocyanide (PhCH2NC) ligand. Through a salt metathesis reaction, the chloride ligand in 1 was replaced by potassium benzothiazole-2-thiolate (Kbt) and potassium benzoimidazole-2-thiolate (Kbi) to a...
متن کاملCatalytic organometallic anticancer complexes.
Organometallic complexes offer chemistry that is not accessible to purely organic molecules and, hence, potentially new mechanisms of drug action. We show here that the presence of both an iodido ligand and a sigma-donor/pi-acceptor phenylazopyridine ligand confers remarkable inertness toward ligand substitution on the half-sandwich "piano-stool" ruthenium arene complexes [(eta(6)-arene)Ru(azpy...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Organometallics
سال: 2019
ISSN: 0276-7333,1520-6041
DOI: 10.1021/acs.organomet.9b00627